Gelatinolytic Activity in Atherosclerotic Plaques Is Highly Localized and Is Associated With Both Macrophages and Smooth Muscle Cells In Vivo | Zendy

Dolf Segers | Zendy; Frank Helderman | Zendy; Caroline Cheng | Zendy; Luc C.A. van Damme | Zendy; Dennie Tempel | Zendy; Eric Boersma | Zendy; Patrick W. Serruys | Zendy; Rini de Crom | Zendy; Antonius F.W. van der Steen | Zendy; Paul Holvoet | Zendy; Rob Krams | Zendy

Open Access

Gelatinolytic Activity in Atherosclerotic Plaques Is Highly Localized and Is Associated With Both Macrophages and Smooth Muscle Cells In Vivo

Author(s) -

Dolf Segers,

Frank Helderman,

Caroline Cheng,

Luc C.A. van Damme,

Dennie Tempel,

Eric Boersma,

Patrick W. Serruys,

Rini de Crom,

Antonius F.W. van der Steen,

Paul Holvoet,

Rob Krams

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.636415

Subject(s) - inflammation , medicine , gelatinase , in vivo , fibrous cap , smooth muscle , macrophage , lipoprotein , colocalization , vascular smooth muscle , aorta , pathology , foam cell , lumen (anatomy) , cholesterol , microbiology and biotechnology , matrix metalloproteinase , in vitro , biology , biochemistry

Atherosclerosis is considered an inflammatory disease. Recent studies provided evidence for a predominant upstream location of plaque inflammation. The present study introduces a novel technique that evaluates the underlying mechanism of this spatial organization.

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