Open AccessCalcific Aortic Valve Stenosis in Old Hypercholesterolemic Mice
Author(s) -
Robert M. Weiss,
Masuo Ohashi,
Jordan D. Miller,
Stephen G. Young,
Donald D. Heistad
Publication year - 2006
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.106.634139
Subject(s) - medicine , stenosis , cardiology , aortic valve , apolipoprotein b , aortic valve stenosis , calcification , ventricle , ejection fraction , ldl receptor , lipoprotein , cholesterol , heart failure
Hypercholesterolemia and old age are clinical risk factors for development of aortic valve stenosis, and hypercholesterolemia is a putative therapeutic target. We tested the hypothesis that calcification and aortic valve stenosis would develop in genetically hypercholesterolemic old mice.
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