Inducible Cardiac-Restricted Expression of Enteroviral Protease 2A Is Sufficient to Induce Dilated Cardiomyopathy | Zendy

Dingding Xiong | Zendy; Toshitaka Yajima | Zendy; Byung-Kwan Lim | Zendy; Antine E. Stenbit | Zendy; Andrew Dublin | Zendy; Nancy D. Dalton | Zendy; Daphne Summers-Torres | Zendy; Jeffery D. Molkentin | Zendy; Hervé Duplain | Zendy; Rainer Wessely | Zendy; Ju Chen | Zendy; Kirk U. Knowlton | Zendy

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Inducible Cardiac-Restricted Expression of Enteroviral Protease 2A Is Sufficient to Induce Dilated Cardiomyopathy

Author(s) -

Dingding Xiong,

Toshitaka Yajima,

Byung-Kwan Lim,

Antine E. Stenbit,

Andrew Dublin,

Nancy D. Dalton,

Daphne Summers-Torres,

Jeffery D. Molkentin,

Hervé Duplain,

Rainer Wessely,

Ju Chen,

Kirk U. Knowlton

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.631093

Subject(s) - tamoxifen , medicine , cardiomyopathy , myocyte , dystrophin , endocrinology , protease , cardiac fibrosis , heart failure , biology , duchenne muscular dystrophy , enzyme , biochemistry , cancer , breast cancer

Enterovirus infection is a cause of cardiomyopathy. We previously demonstrated that enteroviral protease 2A directly cleaves the cytoskeletal protein dystrophin. However, the direct effect of protease 2A in enteroviral cardiomyopathy is less clear because other viral proteins are also expressed with viral infection.

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