Statins Activate AMP-Activated Protein Kinase In Vitro and In Vivo | Zendy

Wei Sun | Zendy; TzongShyuan Lee | Zendy; Minjia Zhu | Zendy; Chunang Gu | Zendy; Yinsheng Wang | Zendy; Yi Zhu | Zendy; John Y.J. Shyy | Zendy

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Statins Activate AMP-Activated Protein Kinase In Vitro and In Vivo

Author(s) -

Wei Sun,

TzongShyuan Lee,

Minjia Zhu,

Chunang Gu,

Yinsheng Wang,

Yi Zhu,

John Y.J. Shyy

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.630194

Subject(s) - ampk , protein kinase a , phosphorylation , amp activated protein kinase , atorvastatin , nitric oxide synthase , medicine , endocrinology , pharmacology , nitric oxide , microbiology and biotechnology , biology

Statins exert pleiotropic effects on the cardiovascular system, in part through an increase in nitric oxide (NO) bioavailability. AMP-activated protein kinase (AMPK) plays a central role in controlling energy and metabolism homeostasis in various organs. We therefore studied whether statins can activate AMPK, and if so, whether the activated AMPK regulates nitric oxide (NO) production and angiogenesis mediated by endothelial NO synthase, a substrate of AMPK in vascular endothelial cells.

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