Long-Term Stimulation of Adenosine A2b Receptors Begun After Myocardial Infarction Prevents Cardiac Remodeling in Rats | Zendy

Masakatsu Wakeno | Zendy; Tetsuo Minamino | Zendy; Osamu Seguchi | Zendy; Hidetoshi Okazaki | Zendy; Osamu Tsukamoto | Zendy; Kenichiro Okada | Zendy; Akio Hirata | Zendy; Masashi Fujita | Zendy; Hiroshi Asanuma | Zendy; Jiyoong Kim | Zendy; Kazuo Komamura | Zendy; Seiji Takashima | Zendy; Naoki Mochizuki | Zendy; Masafumi Kitakaze | Zendy

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Long-Term Stimulation of Adenosine A2b Receptors Begun After Myocardial Infarction Prevents Cardiac Remodeling in Rats

Author(s) -

Masakatsu Wakeno,

Tetsuo Minamino,

Osamu Seguchi,

Hidetoshi Okazaki,

Osamu Tsukamoto,

Kenichiro Okada,

Akio Hirata,

Masashi Fujita,

Hiroshi Asanuma,

Jiyoong Kim,

Kazuo Komamura,

Seiji Takashima,

Naoki Mochizuki,

Masafumi Kitakaze

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.630087

Subject(s) - medicine , adenosine , adenosine receptor , adenosine a1 receptor , stimulation , endocrinology , adenosine receptor antagonist , adenosine a2a receptor , receptor , ventricular remodeling , adenosine a3 receptor , antagonist , myocardial infarction , pharmacology , agonist

Adenosine inhibits proliferation of cardiac fibroblasts and hypertrophy of cardiomyocytes, both of which may play crucial roles in cardiac remodeling. In the present study, we investigated whether chronic stimulation of adenosine receptors begun after myocardial infarction (MI) prevents cardiac remodeling.

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