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Both statins and thiazolidinediones have antiinflammatory properties. However, the exact mechanisms underlying these effects are unknown. We investigated whether atorvastatin (ATV) and pioglitazone (PIO) increase the myocardial content of lipoxin-A4 and 15(R)-epi-lipoxin-A4 (15-epi-LXA4), both arachidonic acid products with strong antiinflammatory properties.

Augmentation of Myocardial Production of 15-Epi-Lipoxin-A4by Pioglitazone and Atorvastatin in the Rat

Augmentation of Myocardial Production of 15-Epi-Lipoxin-A₄by Pioglitazone and Atorvastatin in the Rat