Augmentation of Myocardial Production of 15-Epi-Lipoxin-A 4 by Pioglitazone and Atorvastatin in the Rat | Zendy

Yochai Birnbaum | Zendy; Yumei Ye | Zendy; Yu Lin | Zendy; Sheldon Y. Freeberg | Zendy; Shawn Nishi | Zendy; Juan D. Martinez | Zendy; Ming-He Huang | Zendy; Barry F. Uretsky | Zendy; J. R. PerezPolo | Zendy

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Augmentation of Myocardial Production of 15-Epi-Lipoxin-A ₄ by Pioglitazone and Atorvastatin in the Rat

Author(s) -

Yochai Birnbaum,

Yumei Ye,

Yu Lin,

Sheldon Y. Freeberg,

Shawn Nishi,

Juan D. Martinez,

Ming-He Huang,

Barry F. Uretsky,

J. R. PerezPolo

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.629907

Subject(s) - zileuton , lipoxin , medicine , cyclooxygenase , atorvastatin , pioglitazone , valdecoxib , pharmacology , lipoxygenase , endocrinology , arachidonate 5 lipoxygenase , arachidonic acid , chemistry , receptor , biochemistry , enzyme , rofecoxib , diabetes mellitus , type 2 diabetes

Both statins and thiazolidinediones have antiinflammatory properties. However, the exact mechanisms underlying these effects are unknown. We investigated whether atorvastatin (ATV) and pioglitazone (PIO) increase the myocardial content of lipoxin-A4 and 15(R)-epi-lipoxin-A4 (15-epi-LXA4), both arachidonic acid products with strong antiinflammatory properties.

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