Real-Time 2-Photon Imaging of Mitochondrial Function in Perfused Rat Hearts Subjected to Ischemia/Reperfusion | Zendy

Madoka Matsumoto-Ida | Zendy; Masaharu Akao | Zendy; Toshihiro Takeda | Zendy; Masashi Kato | Zendy; Toru Kita | Zendy

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Real-Time 2-Photon Imaging of Mitochondrial Function in Perfused Rat Hearts Subjected to Ischemia/Reperfusion

Author(s) -

Madoka Matsumoto-Ida,

Masaharu Akao,

Toshihiro Takeda,

Masashi Kato,

Toru Kita

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.628834

Subject(s) - medicine , ischemia , mitochondrion , cardiology , two photon excitation microscopy , microbiology and biotechnology , fluorescence , optics , physics , biology

Mitochondria play pivotal roles in cell death; the loss of mitochondrial membrane potential (delta psi(m)) is the earliest event that commits the cell to death. Here, we report novel real-time imaging of delta psi(m) in individual cardiomyocytes within perfused rat hearts using 2-photon laser-scanning microscopy, which has unique advantages over conventional confocal microscopy: greater tissue penetration and lower tissue toxicity.

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