Induction of Oral Tolerance to Oxidized Low-Density Lipoprotein Ameliorates Atherosclerosis | Zendy

Gijs H.M. van Puijvelde | Zendy; Arnaud D. Hauer | Zendy; Paul de Vos | Zendy; Rosette Van Den Heuvel | Zendy; Martijn J. C. van Herwijnen | Zendy; Ruurd van der Zee | Zendy; Willem van Eden | Zendy; Th.J.C. van Berkel | Zendy; Johan Kuiper | Zendy

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Induction of Oral Tolerance to Oxidized Low-Density Lipoprotein Ameliorates Atherosclerosis

Author(s) -

Gijs H.M. van Puijvelde,

Arnaud D. Hauer,

Paul de Vos,

Rosette Van Den Heuvel,

Martijn J. C. van Herwijnen,

Ruurd van der Zee,

Willem van Eden,

Th.J.C. van Berkel,

Johan Kuiper

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.615609

Subject(s) - medicine , foxp3 , immune tolerance , il 2 receptor , endocrinology , immune system , lipoprotein , ldl receptor , spleen , immunology , t cell , cholesterol

Oxidation of low-density lipoprotein (LDL) and the subsequent processing of oxidized LDL (oxLDL) by macrophages results in activation of specific T cells, which contributes to the development of atherosclerosis. Oral tolerance induction and the subsequent activation of regulatory T cells may be an adequate therapy for the treatment of atherosclerosis.

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