Critical Time Window for Intra-Arrest Cooling With Cold Saline Flush in a Dog Model of Cardiopulmonary Resuscitation | Zendy

Ala Nozari | Zendy; Peter Šafář | Zendy; S. William Stezoski | Zendy; Xianren Wu | Zendy; Scott Kostelnik | Zendy; Ann Radovsky | Zendy; Samuel A. Tisherman | Zendy; Patrick M. Kochanek | Zendy

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Critical Time Window for Intra-Arrest Cooling With Cold Saline Flush in a Dog Model of Cardiopulmonary Resuscitation

Author(s) -

Ala Nozari,

Peter Šafář,

S. William Stezoski,

Xianren Wu,

Scott Kostelnik,

Ann Radovsky,

Samuel A. Tisherman,

Patrick M. Kochanek

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.613349

Subject(s) - medicine , hypothermia , ventricular fibrillation , anesthesia , cardiopulmonary resuscitation , resuscitation , cardiopulmonary bypass , bolus (digestion) , fibrillation , atrial fibrillation

Mild hypothermia improves outcome when induced after cardiac arrest in humans. Recent studies in both dogs and mice suggest that induction of mild hypothermia during cardiopulmonary resuscitation (CPR) greatly enhances its efficacy. In this study, we evaluate the time window for the beneficial effect of intra-arrest cooling in the setting of prolonged CPR in a clinically relevant large-animal model.

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