Suppression of Atherosclerotic Plaque Progression and Instability by Tissue Inhibitor of Metalloproteinase-2 | Zendy

Jason L. Johnson | Zendy; Andrew H. Baker | Zendy; Kazuhiro Oka | Zendy; Lawrence Chan | Zendy; Andrew C. Newby | Zendy; Christopher L. Jackson | Zendy; Sarah J. George | Zendy

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Suppression of Atherosclerotic Plaque Progression and Instability by Tissue Inhibitor of Metalloproteinase-2

Author(s) -

Jason L. Johnson,

Andrew H. Baker,

Kazuhiro Oka,

Lawrence Chan,

Andrew C. Newby,

Christopher L. Jackson,

Sarah J. George

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.613281

Subject(s) - fibrous cap , lesion , apolipoprotein e , extracellular matrix , medicine , matrix metalloproteinase , tissue inhibitor of metalloproteinase , macrophage , apoptosis , apolipoprotein b , knockout mouse , foam cell , metalloproteinase , pathology , in vitro , cancer research , endocrinology , microbiology and biotechnology , biology , cholesterol , receptor , biochemistry , disease

Matrix metalloproteinase (MMP)-associated extracellular matrix degradation is thought to contribute to the progression and rupture of atherosclerotic plaques. However, direct evidence of this concept remains elusive. We hypothesized that overexpression of tissue inhibitor of metalloproteinase (TIMP)-1 or TIMP-2 would attenuate atherosclerotic plaque development and instability in high fat-fed apolipoprotein E-knockout (apoE(-/-)) mice.

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