Toll-Like Receptor 4 Is Involved in Brain Damage and Inflammation After Experimental Stroke | Zendy

Javier R. Caso | Zendy; Jesús M. Pradillo | Zendy; Olivia Hurtado | Zendy; Pedro Lorenzo | Zendy; Marı́a A. Moro | Zendy; Ignacio Lizasoaín | Zendy

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Toll-Like Receptor 4 Is Involved in Brain Damage and Inflammation After Experimental Stroke

Author(s) -

Javier R. Caso,

Jesús M. Pradillo,

Olivia Hurtado,

Pedro Lorenzo,

Marı́a A. Moro,

Ignacio Lizasoaín

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.603431

Subject(s) - medicine , tlr4 , inflammation , stroke (engine) , ischemia , nitric oxide synthase , receptor , brain damage , innate immune system , microglia , immunology , toll like receptor , brain ischemia , nitric oxide , anesthesia , mechanical engineering , engineering

Stroke is the second to third leading cause of death. Toll-like receptor 4 (TLR4) is a signaling receptor in innate immunity that is a specific immunologic response to systemic bacterial infection and cerebral injury. The role of TLR4 in brain ischemia has not been examined yet. We have therefore investigated whether cerebral ischemia and inflammation produced by permanent occlusion of the middle cerebral artery differ in mice that lack a functional TLR4 signaling pathway.

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