Focal Pharmacological Modulation of Atrioventricular Nodal Conduction via Implantable Catheter | Zendy

Daniel C. Sigg | Zendy; Prasanga Hiniduma-Lokuge | Zendy; James A. Coles | Zendy; Phillip Falkner | Zendy; Rebecca Rose | Zendy; Jon Fredric Urban | Zendy; Michael R. Ujhelyi | Zendy

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Focal Pharmacological Modulation of Atrioventricular Nodal Conduction via Implantable Catheter

Author(s) -

Daniel C. Sigg,

Prasanga Hiniduma-Lokuge,

James A. Coles,

Phillip Falkner,

Rebecca Rose,

Jon Fredric Urban,

Michael R. Ujhelyi

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.609420

Subject(s) - medicine , refractory period , acetylcholine , effective refractory period , atrioventricular block , anesthesia , atrial fibrillation , sinus rhythm , heart rate , cardiology , blood pressure

Pharmacological ventricular rate control is an acceptable atrial fibrillation (AF) therapy limited by systemic toxicity. We postulate that focal catheter-based drug delivery into the atrioventricular nodal (AVN) region may effectively control ventricular rate during AF without systemic toxicity. This study evaluated the effects of focally administered acetylcholine on AVN conduction and refractoriness during sinus rhythm and AF.

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