Relevance of Brain Natriuretic Peptide in Preload-Dependent Regulation of Cardiac Sarcoplasmic Reticulum Ca 2+ ATPase Expression | Zendy

Harald Kögler | Zendy; Peter Schott | Zendy; Karl Toischer | Zendy; Hendrik Milting | Zendy; Phúc Nguyễn Văn | Zendy; Michael Kohlhaas | Zendy; Cornelia Grebe | Zendy; Astrid Kassner | Zendy; Erik Domeier | Zendy; Nils Teucher | Zendy; Tim Seidler | Zendy; Ralph Knöll | Zendy; Lars S. Maier | Zendy; Aly ElBanayosy | Zendy; Reiner Körfer | Zendy; Gerd Hasenfuß | Zendy

Open Access

Relevance of Brain Natriuretic Peptide in Preload-Dependent Regulation of Cardiac Sarcoplasmic Reticulum Ca ²⁺ ATPase Expression

Author(s) -

Harald Kögler,

Peter Schott,

Karl Toischer,

Hendrik Milting,

Phúc Nguyễn Văn,

Michael Kohlhaas,

Cornelia Grebe,

Astrid Kassner,

Erik Domeier,

Nils Teucher,

Tim Seidler,

Ralph Knöll,

Lars S. Maier,

Aly ElBanayosy,

Reiner Körfer,

Gerd Hasenfuß

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.608828

Subject(s) - serca , medicine , preload , endocrinology , heart failure , cyclic guanosine monophosphate , contractility , phospholamban , brain natriuretic peptide , protein kinase a , downregulation and upregulation , atpase , kinase , chemistry , biology , microbiology and biotechnology , hemodynamics , nitric oxide , biochemistry , enzyme , gene

In heart failure (HF), ventricular myocardium expresses brain natriuretic peptide (BNP). Despite the association of elevated serum levels with poor prognosis, BNP release is considered beneficial because of its antihypertrophic, vasodilating, and diuretic properties. However, there is evidence that BNP-mediated signaling may adversely influence cardiac remodeling, with further impairment of calcium homeostasis.

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