Neutralization of Interleukin-18 Inhibits Neointimal Formation in a Rat Model of Vascular Injury | Zendy

Pasquale Maffia | Zendy; Gianluca Grassia | Zendy; Paola Di Meglio | Zendy; Rosa Carnuccio | Zendy; Liberato Berrino | Zendy; Paul Garside | Zendy; Angela Ianaro | Zendy; Armando Ialenti | Zendy

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Neutralization of Interleukin-18 Inhibits Neointimal Formation in a Rat Model of Vascular Injury

Author(s) -

Pasquale Maffia,

Gianluca Grassia,

Paola Di Meglio,

Rosa Carnuccio,

Liberato Berrino,

Paul Garside,

Angela Ianaro,

Armando Ialenti

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.602714

Subject(s) - medicine , neointima , interleukin 1β , interleukin , cardiology , cytokine , restenosis , stent

Studies in humans and animal models suggest that interleukin-18 (IL-18) plays a crucial role in vascular pathologies. IL-18 is a predictor of cardiovascular death in angina and is involved in atherotic plaque destabilization. Higher IL-18 plasma levels also are associated with restenosis after coronary artery angioplasty performed in patients with acute myocardial infarction. We investigated the effective role of IL-18 in neointimal formation in a balloon-induced rat model of vascular injury.

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