Dimethyl Lithospermate B, an Extract of Danshen, Suppresses Arrhythmogenesis Associated With the Brugada Syndrome | Zendy

Jeffrey Fish | Zendy; Daniel R. Welchons | Zendy; Young-Sup Kim | Zendy; SukHo Lee | Zendy; WonKyung Ho | Zendy; Charles Antzelevitch | Zendy

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Dimethyl Lithospermate B, an Extract of Danshen, Suppresses Arrhythmogenesis Associated With the Brugada Syndrome

Author(s) -

Jeffrey Fish,

Daniel R. Welchons,

Young-Sup Kim,

SukHo Lee,

WonKyung Ho,

Charles Antzelevitch

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.601690

Subject(s) - medicine , pinacidil , verapamil , brugada syndrome , ventricular fibrillation , cardiology , repolarization , terfenadine , ventricular tachycardia , tachycardia , pharmacology , endocrinology , electrophysiology , glibenclamide , calcium , diabetes mellitus

Dimethyl lithospermate B (dmLSB) is an extract of Danshen, a traditional Chinese herbal remedy, which slows inactivation of INa, leading to increased inward current during the early phases of the action potential (AP). We hypothesized that this action would be antiarrhythmic in the setting of Brugada syndrome.

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