Cyclic Guanosine Monophosphate Compartmentation in Rat Cardiac Myocytes | Zendy

Liliana Castro | Zendy; Ignácio Verde | Zendy; Dermot M.F. Cooper | Zendy; Rodolphe Fischmeister | Zendy

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Cyclic Guanosine Monophosphate Compartmentation in Rat Cardiac Myocytes

Author(s) -

Liliana Castro,

Ignácio Verde,

Dermot M.F. Cooper,

Rodolphe Fischmeister

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.599241

Subject(s) - medicine , cyclic guanosine monophosphate , guanosine , myocyte , endocrinology , microbiology and biotechnology , biochemistry , biology , nitric oxide

Cyclic guanosine monophosphate (cGMP) is the common second messenger for the cardiovascular effects of nitric oxide (NO) and natriuretic peptides, such as atrial or brain natriuretic peptide, which activate the soluble and particulate forms of guanylyl cyclase, respectively. However, natriuretic peptides and NO donors exert different effects on cardiac and vascular smooth muscle function. We therefore tested whether these differences are due to an intracellular compartmentation of cGMP and evaluated the role of phosphodiesterase (PDE) subtypes in this process.

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