Macrophage Metalloelastase Accelerates the Progression of Atherosclerosis in Transgenic Rabbits | Zendy

Jingyan Liang | Zendy; Enqi Liu | Zendy; Ying Yu | Zendy; Shuji Kitajima | Zendy; Tomonari Koike | Zendy; Yingji Jin | Zendy; Masatoshi Morimoto | Zendy; Kinta Hatakeyama | Zendy; Yujiro Asada | Zendy; Teruo Watanabe | Zendy; Yasuyuki Sasaguri | Zendy; Shigeyuki Watanabe | Zendy; Jianglin Fan | Zendy

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Macrophage Metalloelastase Accelerates the Progression of Atherosclerosis in Transgenic Rabbits

Author(s) -

Jingyan Liang,

Enqi Liu,

Ying Yu,

Shuji Kitajima,

Tomonari Koike,

Yingji Jin,

Masatoshi Morimoto,

Kinta Hatakeyama,

Yujiro Asada,

Teruo Watanabe,

Yasuyuki Sasaguri,

Shigeyuki Watanabe,

Jianglin Fan

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.596031

Subject(s) - medicine , pathogenesis , matrix metalloproteinase , lesion , macrophage , pathological , cholesterol , coronary atherosclerosis , inflammation , pathology , foam cell , endocrinology , lipoprotein , coronary artery disease , biology , in vitro , biochemistry

Macrophage metalloelastase (matrix metalloproteinase [MMP]-12) is upregulated in atherosclerotic lesions and aneurysm; thus, increased MMP-12 activity may play an important role in the pathogenesis of atherosclerosis. However, the pathological roles of MMP-12 in the initiation and progression of atherosclerosis have not been defined.

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