Akt1 Is Required for Physiological Cardiac Growth | Zendy

Brian J. DeBosch | Zendy; Iya Treskov | Zendy; Traian S. Lupu | Zendy; Carla J. Weinheimer | Zendy; Attila Kovács | Zendy; Michael Courtois | Zendy; Anthony J. Muslin | Zendy

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Akt1 Is Required for Physiological Cardiac Growth

Author(s) -

Brian J. DeBosch,

Iya Treskov,

Traian S. Lupu,

Carla J. Weinheimer,

Attila Kovács,

Michael Courtois,

Anthony J. Muslin

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.595231

Subject(s) - medicine , cardiology , akt1 , signal transduction , microbiology and biotechnology , biology , pi3k/akt/mtor pathway

Postnatal growth of the heart chiefly involves nonproliferative cardiomyocyte enlargement. Cardiac hypertrophy exists in a "physiological" form that is an adaptive response to long-term exercise training and as a "pathological" form that often is a maladaptive response to provocative stimuli such as hypertension and aortic valvular stenosis. A signaling cascade that includes the protein kinase Akt regulates the growth and survival of many cell types, but the precise role of Akt1 in either form of cardiac hypertrophy is unknown.

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