Open AccessEffects of Conjugated Equine Estrogen on Stroke in the Women’s Health Initiative
Author(s) -
Susan L. Hendrix,
Sylvia WassertheilSmoller,
Karen Johnson,
Barbara V. Howard,
Charles Kooperberg,
Jacques E. Rossouw,
Maurizio Trevisan,
Aaron K. Aragaki,
Alison E. Baird,
Paul F. Bray,
Julie E. Buring,
Michael H. Criqui,
David M. Herrington,
J.A. Lynch,
Stephen R. Rapp,
James C. Torner
Publication year - 2006
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.105.594077
Subject(s) - medicine , women's health initiative , stroke (engine) , placebo , aspirin , estrogen , hazard ratio , clinical trial , menopause , randomized controlled trial , gynecology , physical therapy , postmenopausal women , confidence interval , pathology , alternative medicine , mechanical engineering , engineering
The Women's Health Initiative (WHI) Estrogen Alone trial assessed the balance of benefits and risks of hormone use in healthy postmenopausal women. The trial was stopped prematurely because there was no benefit for coronary heart disease and an increased risk of stroke. This report provides a thorough analysis of the stroke finding using the final results from the completed trial database.
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