Cyclooxygenase-1 Deficiency in Bone Marrow Cells Increases Early Atherosclerosis in Apolipoprotein E– and Low-Density Lipoprotein Receptor–Null Mice | Zendy

Vladimir R. Babaev | Zendy; Lei Ding | Zendy; Jeff Reese | Zendy; Jason D. Morrow | Zendy; Matthew D. Breyer | Zendy; Sudhansu K. Dey | Zendy; Sergio Fazio | Zendy; MacRae F. Linton | Zendy

Open Access

Cyclooxygenase-1 Deficiency in Bone Marrow Cells Increases Early Atherosclerosis in Apolipoprotein E– and Low-Density Lipoprotein Receptor–Null Mice

Author(s) -

Vladimir R. Babaev,

Lei Ding,

Jeff Reese,

Jason D. Morrow,

Matthew D. Breyer,

Sudhansu K. Dey,

Sergio Fazio,

MacRae F. Linton

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.591537

Subject(s) - medicine , apolipoprotein e , bone marrow , ldl receptor , endocrinology , cyclooxygenase , lipoprotein , apolipoprotein b , cholesterol , enzyme , biology , biochemistry , disease

Cyclooxygenase-1 (COX-1) has been implicated in the pathogenesis of atherothrombosis and is expressed by the major cell types of atherosclerotic lesions. COX-1-mediated platelet thromboxane (TX) production has been proposed to promote both early atherosclerosis and thrombosis. Here, we examined the impact of COX-1 deficiency in bone marrow-derived cells on early atherogenesis in the mouse.

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