In Vivo Evidence for Nitric Oxide–Mediated Calcium-Activated Potassium-Channel Activation During Human Endotoxemia | Zendy

Peter Pickkers | Zendy; Mirrin J. Dorresteijn | Zendy; Martijn P. W. J. M. Bouw | Zendy; Johannes G. van der Hoeven | Zendy; Paul Smits | Zendy

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In Vivo Evidence for Nitric Oxide–Mediated Calcium-Activated Potassium-Channel Activation During Human Endotoxemia

Author(s) -

Peter Pickkers,

Mirrin J. Dorresteijn,

Martijn P. W. J. M. Bouw,

Johannes G. van der Hoeven,

Paul Smits

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.590232

Subject(s) - vasoconstriction , medicine , norepinephrine , tetraethylammonium chloride , endocrinology , nitric oxide synthase , omega n methylarginine , channel blocker , nitric oxide , anesthesia , potassium , calcium , chemistry , dopamine , organic chemistry

During septic shock, the vasoconstrictor response to norepinephrine is seriously blunted. Animal experiments suggest that hyperpolarization of smooth muscle cells by opening of potassium (K) channels underlies this phenomenon. In the present study, we examined whether K-channel blockers and/or nitric oxide (NO) synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.

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