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Increase in Vascular Permeability and Vasodilation Are Critical for Proangiogenic Effects of Stem Cell Therapy
Author(s) -
Dong Gil You,
Ludovic Waeckel,
Téni G. Ebrahimian,
Olivier BlancBrude,
Philippe Foubert,
Véronique Barateau,
Micheline Duriez,
Sophie LeRicousse-Roussanne,
José Vilar,
Elisabetta Dejana,
G Tobelem,
Bernard Lévy,
JeanSébastien Silvestre
Publication year - 2006
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.105.589937
Subject(s) - progenitor cell , medicine , vasodilation , enos , cd34 , stem cell , vascular permeability , endothelial stem cell , nitric oxide , angiogenesis , arteriogenesis , microbiology and biotechnology , bone marrow , cancer research , immunology , nitric oxide synthase , biology , in vitro , biochemistry
Proangiogenic cell therapy based on administration of bone marrow-derived mononuclear cells (BMCs) or endothelial progenitor cells (EPCs) is now under investigation in humans for the treatment of ischemic diseases. However, mechanisms leading to the beneficial effects of BMCs and EPCs remain unclear.

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