Uptake of Cardiovascular Drugs Into the Human Heart | Zendy

Markus Grube | Zendy; Henriette E. Meyer zu Schwabedissen | Zendy; Damaris Präger | Zendy; Jeanette Haney | Zendy; Klaus-Uwe Möritz | Zendy; Konrad Meissner | Zendy; Dieter Rosskopf | Zendy; Lothar Eckel | Zendy; Michael Böhm | Zendy; Gabriele Jedlitschky | Zendy; Heyo K. Kroemer | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Uptake of Cardiovascular Drugs Into the Human Heart

Author(s) -

Markus Grube,

Henriette E. Meyer zu Schwabedissen,

Damaris Präger,

Jeanette Haney,

Klaus-Uwe Möritz,

Konrad Meissner,

Dieter Rosskopf,

Lothar Eckel,

Michael Böhm,

Gabriele Jedlitschky,

Heyo K. Kroemer

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.586107

Subject(s) - verapamil , pharmacology , atp binding cassette transporter , organic cation transport proteins , carnitine , transporter , biology , gene expression , solute carrier family , microbiology and biotechnology , medicine , biochemistry , gene , calcium

To date, the uptake of drugs into the human heart by transport proteins is poorly understood. A candidate protein is the organic cation transporter novel type 2 (OCTN2) (SLC22A5), physiologically acting as a sodium-dependent transport protein for carnitine. We investigated expression and localization of OCTN2 in the human heart, uptake of drugs by OCTN2, and functional coupling of OCTN2 with the eliminating ATP-binding cassette (ABC) transporter ABCB1 (P-glycoprotein).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research