Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1 +/− Haploinsufficient Mice | Zendy

Yoshiyuki Rikitake | Zendy; Naotsugu Oyama | Zendy; Chao-Yung C. Wang | Zendy; Kensuke Noma | Zendy; Minoru Satoh | Zendy; Hyung-Hwan Kim | Zendy; James K. Liao | Zendy

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Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1 ^+/− Haploinsufficient Mice

Author(s) -

Yoshiyuki Rikitake,

Naotsugu Oyama,

Chao-Yung C. Wang,

Kensuke Noma,

Minoru Satoh,

Hyung-Hwan Kim,

James K. Liao

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.584623

Subject(s) - medicine , endocrinology , fibrosis , rock1 , cardiac fibrosis , muscle hypertrophy , angiotensin ii , ctgf , cardiac function curve , blood pressure , heart failure , biology , growth factor , kinase , protein kinase a , microbiology and biotechnology , receptor

Rho GTPase and its downstream target, Rho-associated kinase (ROCK), have been implicated in diverse cardiovascular diseases such as cardiac hypertrophy. However, pharmacological inhibitors of ROCK are not entirely specific, nor can they discriminate between the ROCK isoforms ROCK1 and ROCK2. To determine the specific role of ROCK1 in the development of cardiac hypertrophy, we generated ROCK1(+/-) haploinsufficient mice and determined whether cardiac hypertrophy and remodeling are decreased in these mice.

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