Urocortin

whoreportedthatageneticallyalteredmousemodeldeficient of the receptor to which urocortin II binds wascharacterized by hypertension, whereas infusion of urocortin IIinto cardiomyopathic mice enhanced myocardial performanceand decreased systemic vascular resistance. These works andthose of others have provided increased momentum into basicand clinical research into this humoral system as it relates tocardiovascular disease, especially heart failure (HF).