Stent-Based Local Delivery of Nuclear Factor-κB Decoy Attenuates In-Stent Restenosis in Hypercholesterolemic Rabbits | Zendy

Kisho Ohtani | Zendy; Kensuke Egashira | Zendy; Kaku Nakano | Zendy; Gang Zhao | Zendy; Kouta Funakoshi | Zendy; Yoshiko Ihara | Zendy; Satoshi Kimura | Zendy; Ryuji Tominaga | Zendy; Ryuichi Morishita | Zendy; Kenji Sunagawa | Zendy

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Stent-Based Local Delivery of Nuclear Factor-κB Decoy Attenuates In-Stent Restenosis in Hypercholesterolemic Rabbits

Author(s) -

Kisho Ohtani,

Kensuke Egashira,

Kaku Nakano,

Gang Zhao,

Kouta Funakoshi,

Yoshiko Ihara,

Satoshi Kimura,

Ryuji Tominaga,

Ryuichi Morishita,

Kenji Sunagawa

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.582254

Subject(s) - decoy , restenosis , medicine , stent , inflammation , monocyte , vascular smooth muscle , cancer research , receptor , smooth muscle

Nuclear factor-kappaB (NF-kappaB) plays a critical role in the vascular response to injury. However, the role of NF-kappaB in the mechanism of in-stent restenosis remains unclear. We therefore tested the hypothesis that blockade of NF-kappaB by stent-based delivery of a cis-element "decoy" of NF-kappaB reduces in-stent neointimal formation.

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