Activation of Soluble Guanylate Cyclase Reverses Experimental Pulmonary Hypertension and Vascular Remodeling | Zendy

Rio Dumitrascu | Zendy; Norbert Weißmann | Zendy; Hossein A. Ghofrani | Zendy; Eva Dony | Zendy; Knut Beuerlein | Zendy; Harald Schmidt | Zendy; JohannesPeter Stasch | Zendy; Mark Jean Gnoth | Zendy; Werner Seeger | Zendy; Friedrich Grimminger | Zendy; Ralph T. Schermuly | Zendy

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Activation of Soluble Guanylate Cyclase Reverses Experimental Pulmonary Hypertension and Vascular Remodeling

Author(s) -

Rio Dumitrascu,

Norbert Weißmann,

Hossein A. Ghofrani,

Eva Dony,

Knut Beuerlein,

Harald Schmidt,

JohannesPeter Stasch,

Mark Jean Gnoth,

Werner Seeger,

Friedrich Grimminger,

Ralph T. Schermuly

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.581405

Subject(s) - pulmonary hypertension , medicine , right ventricular hypertrophy , hypoxia (environmental) , nitric oxide , lung , soluble guanylyl cyclase , endocrinology , muscle hypertrophy , pulmonary artery , vascular remodelling in the embryo , vascular resistance , nitric oxide synthase , hemodynamics , cardiology , guanylate cyclase , oxygen , chemistry , organic chemistry

Severe pulmonary hypertension is a disabling disease with high mortality, characterized by pulmonary vascular remodeling and right heart hypertrophy. Using wild-type and homozygous endothelial nitric oxide synthase (NOS3(-/-)) knockout mice with pulmonary hypertension induced by chronic hypoxia and rats with monocrotaline-induced pulmonary hypertension, we examined whether the soluble guanylate cyclase (sGC) stimulator Bay41-2272 or the sGC activator Bay58-2667 could reverse pulmonary vascular remodeling.

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