Glycated Proteins Stimulate Reactive Oxygen Species Production in Cardiac Myocytes | Zendy

Min Zhang | Zendy; Ay Lin Kho | Zendy; Narayana Anilkumar | Zendy; Rakesh Chibber | Zendy; Patrick J. Pagano | Zendy; Ajay M. Shah | Zendy; Alison Cave | Zendy

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Glycated Proteins Stimulate Reactive Oxygen Species Production in Cardiac Myocytes

Author(s) -

Min Zhang,

Ay Lin Kho,

Narayana Anilkumar,

Rakesh Chibber,

Patrick J. Pagano,

Ajay M. Shah,

Alison Cave

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.581397

Subject(s) - medicine , myocyte , reactive oxygen species , oxygen , microbiology and biotechnology , cardiology , endocrinology , biology , chemistry , organic chemistry

Nonenzymatic glycation that results in the production of early-glycation Amadori-modified proteins and advanced-glycation end products may be important in the pathogenesis of diabetic complications. However, the effects of early-glycated proteins, such as glycated serum albumin (Gly-BSA), are poorly defined. In this study, we investigated the effects of Gly-BSA on reactive oxygen species (ROS) production by cardiomyocytes.

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