VKORC1 Haplotypes Are Associated With Arterial Vascular Diseases (Stroke, Coronary Heart Disease, and Aortic Dissection) | Zendy

Yibo Wang | Zendy; Weili Zhang | Zendy; Yuhui Zhang | Zendy; Yuejin Yang | Zendy; Lizhong Sun | Zendy; Sunli Hu | Zendy; Jilin Chen | Zendy; Channa Zhang | Zendy; Yi Zheng | Zendy; Yang Zhen | Zendy; Kai Sun | Zendy; Chenbo Fu | Zendy; Tao Yang | Zendy; Jianwei Wang | Zendy; Jing Sun | Zendy; Haiying Wu | Zendy; Wayne C. Glasgow | Zendy; Rutai Hui | Zendy

Open Access

VKORC1 Haplotypes Are Associated With Arterial Vascular Diseases (Stroke, Coronary Heart Disease, and Aortic Dissection)

Author(s) -

Yibo Wang,

Weili Zhang,

Yuhui Zhang,

Yuejin Yang,

Lizhong Sun,

Sunli Hu,

Jilin Chen,

Channa Zhang,

Yi Zheng,

Yang Zhen,

Kai Sun,

Chenbo Fu,

Tao Yang,

Jianwei Wang,

Jing Sun,

Haiying Wu,

Wayne C. Glasgow,

Rutai Hui

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.580167

Subject(s) - medicine , single nucleotide polymorphism , haplotype , cardiology , vkorc1 , odds ratio , vitamin k epoxide reductase , stroke (engine) , gastroenterology , endocrinology , allele , genotype , biology , genetics , cyp2c9 , cytochrome p450 , metabolism , gene , engineering , mechanical engineering

The haplotypes in the gene vitamin K epoxide reductase complex subunit 1 (VKORC1) have been found to affect warfarin dose response through effects on the formation of reduced-form vitamin K, a cofactor for gamma-carboxylation of vitamin K-dependent proteins, which is involved in the coagulation cascade and has a potential impact on atherosclerosis. We hypothesized that VKORC1-dependent effects on the coagulation cascade and atherosclerosis would contribute to susceptibility for vascular diseases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research