NAD(P)H Oxidase and Multidrug Resistance Protein Genetic Polymorphisms Are Associated With Doxorubicin-Induced Cardiotoxicity | Zendy

Leszek Wojnowski | Zendy; Bettina Kulle | Zendy; Markus Schirmer | Zendy; Gregor Schlüter | Zendy; Albrecht Schmidt | Zendy; Albert Rosenberger | Zendy; Stefan Vonhof | Zendy; Heike Bickeböller | Zendy; Mohammad R. Toliat | Zendy; Eun-Kyung Suk | Zendy; Mladen V. Tzvetkov | Zendy; Anke Krüger | Zendy; S. Seifert | Zendy; Marita Kloess | Zendy; Heidi Hahn | Zendy; Markus Loeffler | Zendy; Peter Nürnberg | Zendy; Michael Pfreundschuh | Zendy; Lorenz Trümper | Zendy; Jürgen Brockmöller | Zendy; Gerd Hasenfuß | Zendy

Open Access

NAD(P)H Oxidase and Multidrug Resistance Protein Genetic Polymorphisms Are Associated With Doxorubicin-Induced Cardiotoxicity

Author(s) -

Leszek Wojnowski,

Bettina Kulle,

Markus Schirmer,

Gregor Schlüter,

Albrecht Schmidt,

Albert Rosenberger,

Stefan Vonhof,

Heike Bickeböller,

Mohammad R. Toliat,

Eun-Kyung Suk,

Mladen V. Tzvetkov,

Anke Krüger,

S. Seifert,

Marita Kloess,

Heidi Hahn,

Markus Loeffler,

Peter Nürnberg,

Michael Pfreundschuh,

Lorenz Trümper,

Jürgen Brockmöller,

Gerd Hasenfuß

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.576850

Subject(s) - medicine , cardiotoxicity , doxorubicin , multiple drug resistance , pharmacology , nad+ kinase , genetics , drug resistance , chemotherapy , enzyme , biochemistry , biology

A significant number of patients treated with anthracyclines develop cardiotoxicity (anthracycline-induced cardiotoxicity [ACT]), mainly presenting as arrhythmias (acute ACT) or congestive heart failure (chronic ACT). There are no data on pharmacogenomic predictors of ACT.

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