Mineralocorticoid Receptor Antagonism Ameliorates Left Ventricular Diastolic Dysfunction and Myocardial Fibrosis in Mildly Symptomatic Patients With Idiopathic Dilated Cardiomyopathy | Zendy

Hideo Izawa | Zendy; Toyoaki Murohara | Zendy; Kohzo Nagata | Zendy; Satoshi Isobe | Zendy; Hiroyuki Asano | Zendy; Tetsuya Amano | Zendy; Sahoko Ichihara | Zendy; Tomoko S. Kato | Zendy; Satoru Ohshima | Zendy; Yosuke Murase | Zendy; Shigeo Iino | Zendy; Koji Obata | Zendy; Akiko Noda | Zendy; Kenji Okumura | Zendy; Mitsuhiro Yokota | Zendy

Open Access

Mineralocorticoid Receptor Antagonism Ameliorates Left Ventricular Diastolic Dysfunction and Myocardial Fibrosis in Mildly Symptomatic Patients With Idiopathic Dilated Cardiomyopathy

Author(s) -

Hideo Izawa,

Toyoaki Murohara,

Kohzo Nagata,

Satoshi Isobe,

Hiroyuki Asano,

Tetsuya Amano,

Sahoko Ichihara,

Tomoko S. Kato,

Satoru Ohshima,

Yosuke Murase,

Shigeo Iino,

Koji Obata,

Akiko Noda,

Kenji Okumura,

Mitsuhiro Yokota

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.571653

Subject(s) - medicine , mineralocorticoid receptor , cardiology , dilated cardiomyopathy , myocardial fibrosis , diastole , cardiomyopathy , eplerenone , mineralocorticoid , fibrosis , antagonism , heart failure , aldosterone , receptor , blood pressure

Mineralocorticoid receptor antagonism reduces mortality associated with heart failure by mechanisms that remain unclear. The effects of the mineralocorticoid receptor antagonist spironolactone on left ventricular (LV) function and chamber stiffness associated with myocardial fibrosis were investigated in mildly symptomatic patients with idiopathic dilated cardiomyopathy (DCM).

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