Open AccessExtracellular Matrix Metalloproteinase Inducer Regulates Matrix Metalloproteinase Activity in Cardiovascular Cells
Author(s) -
Roland Schmidt,
Andreas Bültmann,
Martin Ungerer,
Nader Joghetaei,
özgür B. Bülbül,
Sven F. Thieme,
Triantafyllos Chavakis,
Bryan P. Toole,
Meinrad Gawaz,
Albert Schömig,
Andreas E. May
Publication year - 2006
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.105.568162
Subject(s) - basigin , matrix metalloproteinase , metalloproteinase , medicine , downregulation and upregulation , monocyte , extracellular matrix , zymography , cancer research , flow cytometry , secretion , gene silencing , inflammation , microbiology and biotechnology , immunology , chemistry , biology , biochemistry , gene
Matrix metalloproteinases (MMPs) are thought to promote progression of atherosclerosis and cardiovascular complications such as plaque rupture. It has been suggested that, on tumor cells, the extracellular MMP inducer (EMMPRIN) is involved in MMP synthesis by as yet unknown mechanisms. On cardiovascular cells, regulation of EMMPRIN in vivo or any functional relevance for MMP induction in vitro has not yet been studied. Thus, we studied EMMPRIN expression on monocytes in acute myocardial infarction (MI) and its potential relevance for MMP activation.
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