Low-Density Lipoprotein Receptor Genotype and Response to Pravastatin in Children With Familial Hypercholesterolemia | Zendy

Kristel C.M.C. Koeijvoets | Zendy; Jessica Rodenburg | Zendy; Barbara A. Hutten | Zendy; Albert Wiegman | Zendy; John J.P. Kastelein | Zendy; Eric J.G. Sijbrands | Zendy

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Low-Density Lipoprotein Receptor Genotype and Response to Pravastatin in Children With Familial Hypercholesterolemia

Author(s) -

Kristel C.M.C. Koeijvoets,

Jessica Rodenburg,

Barbara A. Hutten,

Albert Wiegman,

John J.P. Kastelein,

Eric J.G. Sijbrands

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.565507

Subject(s) - medicine , familial hypercholesterolemia , pravastatin , ldl receptor , genotype , lipoprotein , endocrinology , genetics , cholesterol , gene , biology

The lipid-lowering effects of statin therapy show considerable interindividual variation in patients with familial hypercholesterolemia (FH). Whether the type of LDL receptor mutation predicts the response to statin treatment is not yet established. We analyzed the relationship between LDL receptor genotype and response to pravastatin treatment in children with FH using carotid intima-media thickness (IMT) to measure efficacy.

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