Open AccessMyD88 Signaling Controls Autoimmune Myocarditis Induction
Author(s) -
René R. Marty,
Stephan Dirnhofer,
Nora Mauermann,
Sacha Schweikert,
Shizuo Akira,
Lukas Hunziker,
Josef Penninger,
Urs Eriksson
Publication year - 2006
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.105.564294
Subject(s) - myocarditis , medicine , autoimmunity , immunology , t cell , tumor necrosis factor alpha , cardiomyopathy , immune system , heart failure
Experimental autoimmune myocarditis (EAM) is a CD4+ T-cell-mediated mouse model of postviral cardiomyopathy. Activation of interleukin-1 type 1 and Toll-like receptors that share the common downstream adaptor molecule MyD88 is required for disease induction. The specific role of MyD88 in myocarditis, however, is not known.
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