Glycogen Synthase Kinase-3 Mediates Endothelial Cell Activation by Tumor Necrosis Factor-α | Zendy

Masato Eto | Zendy; Alexei Kouroedov | Zendy; Francesco Cosentino | Zendy; Thomas F. Lüscher | Zendy

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Glycogen Synthase Kinase-3 Mediates Endothelial Cell Activation by Tumor Necrosis Factor-α

Author(s) -

Masato Eto,

Alexei Kouroedov,

Francesco Cosentino,

Thomas F. Lüscher

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.564112

Subject(s) - gsk 3 , gsk3b , tumor necrosis factor alpha , endothelial stem cell , glycogen synthase , tissue factor , signal transduction , biology , phosphorylation , microbiology and biotechnology , cancer research , endocrinology , medicine , biochemistry , coagulation , in vitro

Endothelial cell transformation to a thrombogenic and inflammatory phenotype plays an important role in the pathogenesis of atherothrombosis, but the responsible signaling pathways remain to be elucidated. This study was designed to investigate the regulatory role of glycogen synthase kinase-3 (GSK-3) in tissue factor (TF) and vascular cell adhesion molecule (VCAM)-1 expression in tumor necrosis factor (TNF)-alpha-stimulated endothelial cells.

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