TRPV1 Gene Knockout Impairs Postischemic Recovery in Isolated Perfused Heart in Mice | Zendy

Lihong Wang | Zendy; Donna H. Wang | Zendy

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TRPV1 Gene Knockout Impairs Postischemic Recovery in Isolated Perfused Heart in Mice

Author(s) -

Lihong Wang,

Donna H. Wang

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.556274

Subject(s) - capsazepine , calcitonin gene related peptide , trpv1 , medicine , endocrinology , receptor antagonist , ischemia , substance p , antagonist , receptor , neuropeptide , transient receptor potential channel

Although pharmacological studies suggest that the transient receptor potential vanilloid type 1 (TRPV1) channels expressed in sensory nerve fibers innervating the heart may exert a cardioprotective effect, definitive evidence supporting such a notion is lacking. In addition, function and regulation of sensory neuropeptides, namely, calcitonin gene-related peptide (CGRP) and substance P (SP), in the face of challenges induced by cardiac injury in the presence or absence of the TRPV1 are largely unknown.

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