Nebivolol Reduces Nitroxidative Stress and Restores Nitric Oxide Bioavailability in Endothelium of Black Americans | Zendy

Ronald P. Mason | Zendy; Leszek Kalinowski | Zendy; Robert F. Jacob | Zendy; Adam Jacoby | Zendy; Tadeusz Maliñski | Zendy

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Nebivolol Reduces Nitroxidative Stress and Restores Nitric Oxide Bioavailability in Endothelium of Black Americans

Author(s) -

Ronald P. Mason,

Leszek Kalinowski,

Robert F. Jacob,

Adam Jacoby,

Tadeusz Maliñski

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.556233

Subject(s) - nebivolol , peroxynitrite , apocynin , nitric oxide , medicine , endothelial dysfunction , endothelium , bioavailability , pharmacology , oxidative stress , vasodilation , endocrinology , umbilical vein , superoxide , biochemistry , chemistry , nadph oxidase , in vitro , blood pressure , enzyme

Alterations in endothelial function may contribute to increased susceptibility of black Americans to cardiovascular disease. The ability to pharmacologically reverse endothelial dysfunction in blacks was tested with nebivolol, a beta1-selective agent with vasodilating and antioxidant properties.

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