Endogenous Ouabain | Zendy

Julie Murrell | Zendy; Jeffrey Randall | Zendy; James Rosoff | Zendy; Ji-liang Zhao | Zendy; Roderick V. Jensen | Zendy; Steven R. Gullans | Zendy; Garner T. Haupert | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Endogenous Ouabain

Author(s) -

Julie Murrell,

Jeffrey Randall,

James Rosoff,

Ji-liang Zhao,

Roderick V. Jensen,

Steven R. Gullans,

Garner T. Haupert

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.554071

Subject(s) - ouabain , cardiac glycoside , gene knockdown , gene expression , gene , cardenolide , medicine , enzyme , microarray analysis techniques , biochemistry , endocrinology , microbiology and biotechnology , biology , chemistry , glycoside , stereochemistry , organic chemistry , sodium

Mammalian tissues contain a presumed endogenous Na+, K(+)-ATPase inhibitor that binds reversibly to the Na+ pump with high affinity and specificity. The inhibitor has been linked to the pathogenesis of experimental volume-expanded and human essential hypertension. This compound has been isolated from mammalian hypothalamus and appears to be an isomer of the plant-derived cardiac glycoside ouabain, if not ouabain itself. The objective of this study was to test the hypothesis that a biosynthetic pathway exists in mammalian tissues to produce a steroid derivative closely related to plant cardiac glycosides.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research