Notch Signaling Regulates Endothelial Progenitor Cell Activity During Recovery From Arterial Injury in Hypercholesterolemic Mice | Zendy

Masaaki Ii | Zendy; Kyosuke Takeshita | Zendy; Kayoko Ibusuki | Zendy; Corinne Luedemann | Zendy; Andrea Wecker | Zendy; Elizabeth Eaton | Zendy; Tina Thorne | Zendy; Takayuki Asahara | Zendy; James K. Liao | Zendy; Douglas W. Losordo | Zendy

Open Access

Notch Signaling Regulates Endothelial Progenitor Cell Activity During Recovery From Arterial Injury in Hypercholesterolemic Mice

Author(s) -

Masaaki Ii,

Kyosuke Takeshita,

Kayoko Ibusuki,

Corinne Luedemann,

Andrea Wecker,

Elizabeth Eaton,

Tina Thorne,

Takayuki Asahara,

James K. Liao,

Douglas W. Losordo

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.553917

Subject(s) - medicine , notch signaling pathway , progenitor cell , endothelial progenitor cell , endothelial stem cell , endothelium , microbiology and biotechnology , stem cell , receptor , biochemistry , biology , in vitro

Little is known about the role of endothelial progenitor cells (EPCs) in atherosclerosis. Accordingly, we performed a series of assessments with hypercholesterolemic (apolipoprotein E-null [ApoE(-/-)]) and wild-type (WT) mice to evaluate how cholesterol influences reendothelialization, atherosclerosis, and EPC function after arterial injury.

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