Histamine Induces Tissue Factor Expression
Author(s) -
Jan Steffel,
Alexander Akhmedov,
Helen Greutert,
Thomas F. Lüscher,
Felix C. Tanner
Publication year - 2005
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.105.553735
Subject(s) - histamine , medicine , wortmannin , tissue factor , endocrinology , histamine receptor , mapk/erk pathway , ly294002 , mepyramine , p38 mitogen activated protein kinases , kinase , microbiology and biotechnology , pharmacology , receptor , phosphatidylinositol , biology , antagonist , coagulation
Histamine can induce coronary vasospasm, leading to variant angina and acute myocardial infarction. However, the role of histamine in thrombus formation is ill defined. Hence, this study investigates whether histamine induces tissue factor (TF) expression in vascular cells.
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