CD40 Ligand–Dependent Tyrosine Nitration of Prostacyclin Synthase In Vivo | Zendy

Bradley J. Davis | Zendy; Minghui Zou | Zendy

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CD40 Ligand–Dependent Tyrosine Nitration of Prostacyclin Synthase In Vivo

Author(s) -

Bradley J. Davis,

Minghui Zou

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.553206

Subject(s) - peroxynitrite , prostacyclin , nitric oxide synthase , superoxide , medicine , superoxide dismutase , endocrinology , nitric oxide , pharmacology , biochemistry , chemistry , oxidative stress , enzyme

Cells in human atherosclerotic lesions express the immune mediator CD40 and its ligand, CD40L, but the mechanisms and the mediators by which CD40L contributes to atherosclerosis are poorly defined. Here, we show how CD40L increases vascular inflammation and thrombosis via tyrosine nitration and inhibition of prostacyclin synthase (PGIS), an enzyme with antithrombotic, antiproliferative, and dilatory functions in the normal vasculature.

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