Potassium Channel Subunit Remodeling in Rabbits Exposed to Long-Term Bradycardia or Tachycardia | Zendy

Yukiomi Tsuji | Zendy; Stephen Zicha | Zendy; Xiaoyan Qi | Zendy; Itsuo Kodama | Zendy; Stanley Nattel | Zendy

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Potassium Channel Subunit Remodeling in Rabbits Exposed to Long-Term Bradycardia or Tachycardia

Author(s) -

Yukiomi Tsuji,

Stephen Zicha,

Xiaoyan Qi,

Itsuo Kodama,

Stanley Nattel

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.552968

Subject(s) - bradycardia , medicine , tachycardia , ventricular tachycardia , cardiology , sinus bradycardia , dofetilide , heart rate , anesthesia , qt interval , blood pressure

Sustained heart rate abnormalities produce electrical remodeling and susceptibility to arrhythmia. Uncontrolled tachycardia produces heart failure and ventricular tachyarrhythmia susceptibility, whereas bradycardia promotes spontaneous torsade de pointes (TdP). This study compared arrhythmic phenotypes and molecular electrophysiological remodeling produced by tachycardia versus bradycardia in rabbits.

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