Glutaraldehyde-Fixed Bioprosthetic Heart Valve Conduits Calcify and Fail From Xenograft Rejection | Zendy

Rizwan A. Manji | Zendy; Lin Zhu | Zendy; Nimrit K. Nijjar | Zendy; David C. Rayner | Zendy; Greg Korbutt | Zendy; Thomas A. Churchill | Zendy; Ray V. Rajotte | Zendy; Arvind Koshal | Zendy; David B. Ross | Zendy

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Glutaraldehyde-Fixed Bioprosthetic Heart Valve Conduits Calcify and Fail From Xenograft Rejection

Author(s) -

Rizwan A. Manji,

Lin Zhu,

Nimrit K. Nijjar,

David C. Rayner,

Greg Korbutt,

Thomas A. Churchill,

Ray V. Rajotte,

Arvind Koshal,

David B. Ross

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.549311

Subject(s) - adventitia , medicine , calcification , inflammation , dystrophic calcification , cellular infiltration , antigenicity , infiltration (hvac) , macrophage , pathology , transplantation , antibody , glutaraldehyde , immunohistochemistry , heart valve , immunology , biology , biochemistry , physics , in vitro , thermodynamics

Glutaraldehyde fixation (G-F) decreases but likely does not eliminate the antigenicity of bioprosthetic heart valves. Rejection (with secondary dystrophic calcification) may be why G-F xenograft valves fail, especially in young patients, who are more immunocompetent than the elderly. Therefore, we sought to determine whether rejection of G-F xenograft occurs and to correlate this with graft calcification.

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