Estradiol-Mediated Endothelial Nitric Oxide Synthase Association With Heat Shock Protein 90 Requires Adenosine Monophosphate-Dependent Protein Kinase | Zendy

Eberhard Schulz | Zendy; Elad Anter | Zendy; Ming-Hui Zou | Zendy; John F. Keaney | Zendy

Open Access

Estradiol-Mediated Endothelial Nitric Oxide Synthase Association With Heat Shock Protein 90 Requires Adenosine Monophosphate-Dependent Protein Kinase

Author(s) -

Eberhard Schulz,

Elad Anter,

Ming-Hui Zou,

John F. Keaney

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.546812

Subject(s) - medicine , endothelial nitric oxide synthase , heat shock protein , nitric oxide synthase , protein kinase a , adenosine , nitric oxide , endocrinology , shock (circulatory) , microbiology and biotechnology , biochemistry , kinase , enos , biology , gene

Estradiol activates endothelial nitric oxide synthase (eNOS) by mechanisms that involve estrogen receptor-alpha (ERalpha), protein kinase B/Akt, mitogen-activated protein kinases, and heat shock protein 90 (HSP90). Recently, AMP-activated protein kinase (AMPK), an enzyme that plays a crucial role in cellular adaptation to metabolic stress, has been implicated in physiological eNOS activation by the hormones adiponectin and insulin. We therefore investigated whether AMPK is activated by estradiol in endothelial cells and plays a role in estradiol-induced eNOS activation.

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