Blood Flow Remodels Growing Vasculature During Vascular Endothelial Growth Factor Gene Therapy and Determines Between Capillary Arterialization and Sprouting Angiogenesis | Zendy

Tuomas T. Rissanen | Zendy; Petra Korpisalo | Zendy; Johanna E. Markkanen | Zendy; Timo Liimatainen | Zendy; MaijaRiitta Ordén | Zendy; Ivana Kholová | Zendy; Anna de Goede | Zendy; Tommi Heikura | Zendy; Olli Gröhn | Zendy; Seppo YläHerttuala | Zendy

Open Access

Blood Flow Remodels Growing Vasculature During Vascular Endothelial Growth Factor Gene Therapy and Determines Between Capillary Arterialization and Sprouting Angiogenesis

Author(s) -

Tuomas T. Rissanen,

Petra Korpisalo,

Johanna E. Markkanen,

Timo Liimatainen,

MaijaRiitta Ordén,

Ivana Kholová,

Anna de Goede,

Tommi Heikura,

Olli Gröhn,

Seppo YläHerttuala

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.543124

Subject(s) - angiogenesis , vascular endothelial growth factor , arteriogenesis , medicine , blood flow , blood vessel , neovascularization , sprouting angiogenesis , perfusion , artery , growth factor , anatomy , pathology , endocrinology , receptor , vegf receptors

For clinically relevant proangiogenic therapy, it would be essential that the growth of the whole vascular tree is promoted. Vascular endothelial growth factor (VEGF) is well known to induce angiogenesis, but its capability to promote growth of larger vessels is controversial. We hypothesized that blood flow remodels vascular growth during VEGF gene therapy and may contribute to the growth of large vessels.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research