Platelet Adhesion Via Glycoprotein IIb Integrin Is Critical for Atheroprogression and Focal Cerebral Ischemia | Zendy

Steffen Maßberg | Zendy; Katrin Schürzinger | Zendy; Michael Lorenz | Zendy; Ildiko Konrad | Zendy; Christian Schulz | Zendy; Nikolaus Plesnila | Zendy; Elisabeth Kennerknecht | Zendy; Martina Rudelius | Zendy; Susanne K. Sauer | Zendy; Siegmund Braun | Zendy; Elisabeth Kremmer | Zendy; Nikla Emambokus | Zendy; Jon Frampton | Zendy; Meinrad Gawaz | Zendy

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Platelet Adhesion Via Glycoprotein IIb Integrin Is Critical for Atheroprogression and Focal Cerebral Ischemia

Author(s) -

Steffen Maßberg,

Katrin Schürzinger,

Michael Lorenz,

Ildiko Konrad,

Christian Schulz,

Nikolaus Plesnila,

Elisabeth Kennerknecht,

Martina Rudelius,

Susanne K. Sauer,

Siegmund Braun,

Elisabeth Kremmer,

Nikla Emambokus,

Jon Frampton,

Meinrad Gawaz

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.539221

Subject(s) - medicine , integrin , platelet adhesion , focal adhesion , ischemia , glycoprotein , platelet , adhesion , platelet membrane glycoprotein , microbiology and biotechnology , cardiology , immunology , signal transduction , biochemistry , receptor , chemistry , organic chemistry , biology

The platelet glycoprotein (GP) IIb/IIIa integrin binds to fibrinogen and thereby mediates platelet aggregation. Here, we addressed the role of GP IIb for platelet adhesion and determined the relevance of platelet GP IIb for the processes of atherosclerosis and cerebral ischemia-reperfusion (I/R) injury.

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