Open AccessImpaired Impulse Propagation in Scn5a -Knockout Mice
Author(s) -
Toon A.B. van Veen,
Mèra Stein,
Anne Royer,
Khaï Le Quang,
Flavien Charpentier,
William H Colledge,
Christopher Huang,
Ronald Wilders,
Andrew A. Grace,
Denis Escande,
Jacques M.T. de Bakker,
Harold V.M. van Rijen
Publication year - 2005
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.105.539072
Subject(s) - ventricle , medicine , fibrosis , cardiology , nerve conduction velocity , qrs complex
The SCN5A sodium channel is a major determinant for cardiac impulse propagation. We used epicardial mapping of the atria, ventricles, and septae to investigate conduction velocity (CV) in Scn5a heterozygous young and old mice.
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