Oral Human Brain Natriuretic Peptide Activates Cyclic Guanosine 3′,5′-Monophosphate and Decreases Mean Arterial Pressure | Zendy

Alessandro Cataliotti | Zendy; John A. Schirger | Zendy; Fernando L. Martín | Zendy; Horng H. Chen | Zendy; Paul M. McKie | Zendy; Guido Boerrigter | Zendy; Lisa C. Costello-Boerrigter | Zendy; Gail J. Harty | Zendy; Denise M. Heublein | Zendy; Sharon M. Sandberg | Zendy; Kenneth D. James | Zendy; Mark A. Miller | Zendy; Navdeep B. Malkar | Zendy; Karen Polowy | Zendy; John C. Burnett | Zendy

Open Access

Oral Human Brain Natriuretic Peptide Activates Cyclic Guanosine 3′,5′-Monophosphate and Decreases Mean Arterial Pressure

Author(s) -

Alessandro Cataliotti,

John A. Schirger,

Fernando L. Martín,

Horng H. Chen,

Paul M. McKie,

Guido Boerrigter,

Lisa C. Costello-Boerrigter,

Gail J. Harty,

Denise M. Heublein,

Sharon M. Sandberg,

Kenneth D. James,

Mark A. Miller,

Navdeep B. Malkar,

Karen Polowy,

John C. Burnett

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.538520

Subject(s) - medicine , natriuretic peptide , atrial natriuretic peptide , pharmacokinetics , endocrinology , fissipedia , blood pressure , oral administration , crossover study , placebo , pathology , heart failure , alternative medicine

The objective of this study was to address the feasibility and the biological activity of orally administered human brain natriuretic peptide (hBNP). Proprietary technology has been developed in which short, amphiphilic oligomers are covalently attached to peptides. The conjugated peptides are intended to have an improved pharmacokinetic profile and to enable oral administration. We hypothesized that novel oral conjugated hBNP (CONJ-hBNP) increases plasma hBNP, activates cGMP, and reduces mean arterial pressure (MAP).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research