Open AccessPatients With Acute Coronary Syndrome Show Oligoclonal T-Cell Recruitment Within Unstable Plaque
Author(s) -
Raffaele De Palma,
Francesco Del Galdo,
Gianfranco Abbate,
Massimo Chiariello,
Raffaele Calabrò,
Lavinia Forte,
Giovanni Cimmino,
Maria Francesca Papa,
Maria Giovanna Russo,
Giuseppe Ambrosio,
Claudio Giombolini,
Isabella Tritto,
Salvatore Notaristefano,
Liberato Berrino,
Francesco Rossi,
Paolo Golino
Publication year - 2006
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.105.537712
Subject(s) - unstable angina , medicine , acute coronary syndrome , immune system , t cell , pathophysiology , cell , t lymphocyte , inflammation , antigen , immunology , cardiology , pathology , myocardial infarction , biology , genetics
Recent studies indicate that T-cell activation may play an important role in the pathophysiology of acute coronary syndromes (ACS). However, although those studies detected T-cell expansion in peripheral blood cells, demonstration of specific T-cell expansion within the plaque of patients with ACS is lacking. The present study aims to address whether a specific, immune-driven T-lymphocyte recruitment occurs within the unstable plaque of patients with ACS.
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