Genetic Inflammatory Factors Predict Restenosis After Percutaneous Coronary Interventions | Zendy

Pascalle S. Monraats | Zendy; Nuno Pires | Zendy; Willem R.P. Agema | Zendy; Aeilko H. Zwinderman | Zendy; Abbey Schepers | Zendy; Moniek P.M. de Maat | Zendy; Pieter A. Doevendans | Zendy; Robbert J. de Winter | Zendy; René A. Tio | Zendy; Johannes Waltenberger | Zendy; Rune R. Frants | Zendy; Paul H.A. Quax | Zendy; Bart J.M. van Vlijmen | Zendy; Douwe E. Atsma | Zendy; Arnoud van der Laarse | Zendy; Ernst E. van der Wall | Zendy; J. Wouter Jukema | Zendy

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Genetic Inflammatory Factors Predict Restenosis After Percutaneous Coronary Interventions

Author(s) -

Pascalle S. Monraats,

Nuno Pires,

Willem R.P. Agema,

Aeilko H. Zwinderman,

Abbey Schepers,

Moniek P.M. de Maat,

Pieter A. Doevendans,

Robbert J. de Winter,

René A. Tio,

Johannes Waltenberger,

Rune R. Frants,

Paul H.A. Quax,

Bart J.M. van Vlijmen,

Douwe E. Atsma,

Arnoud van der Laarse,

Ernst E. van der Wall,

J. Wouter Jukema

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.536268

Subject(s) - medicine , restenosis , conventional pci , percutaneous coronary intervention , prospective cohort study , cardiology , bioinformatics , myocardial infarction , biology , stent

Restenosis is a negative effect of percutaneous coronary intervention (PCI). No clinical factors are available that allow good risk stratification. However, evidence exists that genetic factors are important in the restenotic process as well as in the process of inflammation, a pivotal factor in restenosis. Association studies have identified genes that may predispose to restenosis, but confirmation by large prospective studies is lacking. Our aim was to identify polymorphisms and haplotypes in genes involved in inflammatory pathways that predispose to restenosis.

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